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Faculty
Rank
Professor
Undergraduate Education
University
of North Carolina at Chapel Hill, Chapel Hill, NC
B.A. (Chemistry), 1975
Graduate
Education
University
of North Carolina at Chapel Hill, Chapel Hill, NC Ph.D.
(Experimental Pathology), 1982
- Thesis on Platelet Factor One in Human Platelets
Postdoctoral Fellowship
UNC
Hospitals, Chapel Hill, NC (Blood Banking), 1982-1984
Research
Interests and Activities
1. Long term
preservation of platelets and red blood cells for
transfusion by freeze-drying. Supported since 1989
by grants from U.S. Office of Naval Research; in
collaboration with Marjorie S. Read, Ph.D., and cohorts
at UNC-Chapel Hill; technology issued patent #5,651,966
and licensed to Cention Pharmaceutics (Kankakee, IL),
nearing clinical trials, two other related patents
pending.
2.
Characterization and inhibition of the platelet storage
lesion with reversible activation inhibitors (liquid
concentrates in blood banking). Supported
previously by grants from U.S. Army Medical Research and
Development Command and The Burroughs Wellcome Fund;
technology issued patent #4,994,367.
3.
Quantitation and characterization of membranous
microparticles released by platelets during activation
or blood bank storage or cardiopulmonary bypass.
Supported previously by a grant-in-aid from American
Heart Association NC Affiliate, SCOR subgrant with
UNC-Chapel Hill, and corporate grants from HemoTec Corp.
(Medtronic subsidiary).
4. Effect of
aprotinin on platelet adhesion. Supported by a
grant from Bayer Corp.; thesis topic for graduate
student John Bradfield in ECU program of Experimental
Pathology.
5.
Development of lyophilized platelet control for the Clot
Signature Analyzer, diagnostic device for assessment of
platelet function. Supported by a grant from Xylum
Corp. (Scarsdale, NY).
Selected
Publications
1.
Bradfield JF, Bode AP. Aprotinin Restores the
Adhesive Capacity of Dysfunctional Platelets.
Thrombosis Research. 2003;109:181-188.
2.
Fischer TH, Russell KE, Bode AP, et al. The
Development of Pro-Hemostatic Lyophilized Platelets with
Minimal Risk for Intravascular Coagulation. Journal
of Thrombosis and Haemeostasis, 2003;1(Suppl
1 July):#OC155.
3.
Fischer TH, Merricks EP, Bode AP, et al. Thrombus
formation with Rehydrated, Lyophilized Platelets.
Hematology. 2002;7:359-369.
4.
Bode AP,
Read MS, Reddick RL. Activation and Adherence of
Lyophilized Human Platelets on Canine Vessel Strips in
the Baumgartner Perfusion Chamber. Journal
Laboratory and Clinical Medicine. 1999; in press,
cover photo for issue.
5.
Dehmer GJ, Nichols TC,
Bode AP,
Liles D, Sigman J, Li S, Koch G, Tate DA, Griggs TR.
Assessment of Platelet Activation by Coronary Sinus
Blood Sampling during Balloon Angioplasty and
Directional Coronary Atherectomy. Am J Cardiol.
1997;80:871-877.
6.
Bode AP,
Read MS, Summaria L, Lust RM. Lyophilized
Platelets; Nearing Clinical Trials. Platelets.
1997;8:436-437.
7.
Lust RM, Bode AP,
Yang L, Hodges W. Chitwood RW. In-Line Leukocyte
Filtration During Bypass - Clinical Results from a
Randomized Prospective Trial. ASAIO Journal.
1996;42:M819-M822.
8.
Read MS, Reddick RL,
Bode AP,
Bellinger DA, Nichols TC, Taylor K, Smith SV, McMahon
DK, Griggs TR, Brinkhouse KM. Preservation of
Hemostatic Function and Structural Properties of
Rehydrated Lyophilized Platelets: Potential for
Long-Term Storage of Dried Platelets for Transfusion.
Proc Natl Acad Sci. 1995;92:397-401.
9.
Warkentin TE, Hayward CPM, Boshkov LK, Santos AV,
Sheppard JAL, Bode
AP, Kelton JG.
Sera from Patients with Heparin-Induced Thrombocytopenia
Generate Platelet-Derived Microparticles with
Procoagulant Activity: An Explanation for the Thrombotic
Complications of Heparin-Induced Thrombocytopenia.
Blood. 1994;84:3691-3699.
10.
Bode AP,
Knupp CL. Effect of Cold Storage on Platelet
Glycoprotein Ib and Vesiculation. Transfusion.
1994;34:690-696.
11.
Bode AP,
Lust RM. Masking of Heparin Activity in the
Activated Coagulation Time [ACT] by Platelet
Procoagulant Activity. Throm Res.
1994;73:285-300.
12.
Demasi R, Bode AP,
Knupp CL, Bogey W, Powell S. Heparin-Induced
Thrombocytopenia. American Surgeon.
1994;60:26-29.
13.
Bode AP,
Holme S, Heaton WAL, Swanson MS. Sustained
Elevation of Intracellular Cyclic 3'-5' Adenosine
Monophosphate is Necessary for Preservation of Platelet
Integrity During Long-Term Storage at 22oC.
Blood. 1994;83:1235-1243.
Selected
Reviews
1.
Hickerson DHM, Bode AP. Flow Cytometry of
Platelets for Clinical Analysis. In Riley R, editor,
Flow Cytometry (special issue of Hematology Oncology
Clinics of North America). WB Saunders.
2002;19(2):421-454.
2. Bode
AP, Read MS. Lyophilized Platelets for Transfusion
Medicine. In Seghatchan J, Snyder EL, eds. Platelet
Therapy: Current Status and Future Challenges.
Amsterdam; Elsevier Science. 2000:131-167.
3.
Krailadsiri P, Seghatchian J,
Bode AP.
Microvesicles in Blood Components: Laboratory and
Clinical Aspects. Clin Appl Thrombosis/Hemostasis.
1997;3:86-95.
Fig 1: Microvesicles in
Blood Components
4.
Read MS, Bode AP.
Platelet Storage: Efforts to Extend the Shelf-Life of
Platelet Concentrates. Molecular Medicine
Today. 1995:1:322-328.
Fig 2: Liquid to
Lyophilized Plt Concentrate
Fig 3: Facets of Storage
Lesion
5.
Bode AP.
Preclinical Testing of Lyophilized Platelets as a
Product of Transfusion Medicine. Transfusion
Science. 1996;16:183-185.
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