Faculty Rank

Professor

Undergraduate Education

University of North Carolina at Chapel Hill, Chapel Hill, NC  B.A. (Chemistry), 1975

Graduate Education

University of North Carolina at Chapel Hill, Chapel Hill, NC Ph.D. (Experimental Pathology), 1982

   - Thesis on Platelet Factor One in Human Platelets

Postdoctoral Fellowship

UNC Hospitals, Chapel Hill, NC (Blood Banking), 1982-1984

Research Interests and Activities

1. Long term preservation of platelets and red blood cells for transfusion by freeze-drying.  Supported since 1989 by grants from U.S. Office of Naval Research; in collaboration with Marjorie S. Read, Ph.D., and cohorts at UNC-Chapel Hill; technology issued patent #5,651,966 and licensed to Cention Pharmaceutics (Kankakee, IL), nearing clinical trials, two other related patents pending.

2. Characterization and inhibition of the platelet storage lesion with reversible activation inhibitors (liquid concentrates in blood banking).  Supported previously by grants from U.S. Army Medical Research and Development Command and The Burroughs Wellcome Fund; technology issued patent #4,994,367.

3. Quantitation and characterization of membranous microparticles released by platelets during activation or blood bank storage or cardiopulmonary bypass.  Supported previously by a grant-in-aid from American Heart Association NC Affiliate, SCOR subgrant with UNC-Chapel Hill, and corporate grants from HemoTec Corp. (Medtronic subsidiary).

4. Effect of aprotinin on platelet adhesion.  Supported by a grant from Bayer Corp.; thesis topic for graduate student John Bradfield in ECU program of Experimental Pathology.

5. Development of lyophilized platelet control for the Clot Signature Analyzer, diagnostic device for assessment of platelet function.  Supported by a grant from Xylum Corp. (Scarsdale, NY).

Selected Publications

1.  Bradfield JF, Bode AP. Aprotinin Restores the Adhesive Capacity of Dysfunctional Platelets. Thrombosis Research. 2003;109:181-188.

2.  Fischer TH, Russell KE, Bode AP, et al. The Development of Pro-Hemostatic Lyophilized Platelets with Minimal Risk for Intravascular Coagulation. Journal of Thrombosis and Haemeostasis, 2003;1(Suppl 1 July):#OC155.

3.  Fischer TH, Merricks EP, Bode AP, et al. Thrombus formation with Rehydrated, Lyophilized Platelets. Hematology. 2002;7:359-369.

4. Bode AP, Read MS, Reddick RL.  Activation and Adherence of Lyophilized Human Platelets on Canine Vessel Strips in the Baumgartner Perfusion Chamber.  Journal Laboratory and Clinical Medicine. 1999; in press, cover photo for issue.

5. Dehmer GJ, Nichols TC, Bode AP, Liles D, Sigman J, Li S, Koch G, Tate DA, Griggs TR.  Assessment of Platelet Activation by Coronary Sinus Blood Sampling during Balloon Angioplasty and Directional Coronary Atherectomy.  Am J Cardiol.  1997;80:871-877.

6. Bode AP, Read MS, Summaria L, Lust RM.  Lyophilized Platelets; Nearing Clinical Trials.  Platelets. 1997;8:436-437.

7. Lust RM, Bode AP, Yang L, Hodges W. Chitwood RW.  In-Line Leukocyte Filtration During Bypass - Clinical Results from a Randomized Prospective Trial.  ASAIO Journal.  1996;42:M819-M822.

8. Read MS, Reddick RL, Bode AP, Bellinger DA, Nichols TC, Taylor K, Smith SV, McMahon DK, Griggs TR, Brinkhouse KM.  Preservation of Hemostatic Function and Structural Properties of Rehydrated Lyophilized Platelets: Potential for Long-Term Storage of Dried Platelets for Transfusion.  Proc Natl Acad Sci.  1995;92:397-401.  

9. Warkentin TE, Hayward CPM, Boshkov LK, Santos AV, Sheppard JAL, Bode AP, Kelton JG.  Sera from Patients with Heparin-Induced Thrombocytopenia Generate Platelet-Derived Microparticles with Procoagulant Activity: An Explanation for the Thrombotic Complications of Heparin-Induced Thrombocytopenia.  Blood.  1994;84:3691-3699.    

10. Bode AP, Knupp CL.  Effect of Cold Storage on Platelet Glycoprotein Ib and Vesiculation.  Transfusion.  1994;34:690-696.

11. Bode AP, Lust RM.  Masking of Heparin Activity in the Activated Coagulation Time [ACT] by Platelet Procoagulant Activity.  Throm Res.  1994;73:285-300.

12. Demasi R, Bode AP, Knupp CL, Bogey W, Powell S.  Heparin-Induced Thrombocytopenia.  American Surgeon.  1994;60:26-29.

13. Bode AP, Holme S, Heaton WAL, Swanson MS.  Sustained Elevation of Intracellular Cyclic 3'-5' Adenosine Monophosphate is Necessary for Preservation of Platelet Integrity During Long-Term Storage at 22^oC.  Blood.  1994;83:1235-1243.

Selected Reviews

1.  Hickerson DHM, Bode AP. Flow Cytometry of Platelets for Clinical Analysis. In Riley R, editor, Flow Cytometry (special issue of Hematology Oncology Clinics of North America). WB Saunders. 2002;19(2):421-454.

2.  Bode AP, Read MS. Lyophilized Platelets for Transfusion Medicine. In Seghatchan J, Snyder EL, eds. Platelet Therapy: Current Status and Future Challenges. Amsterdam; Elsevier Science. 2000:131-167.

3. Krailadsiri P, Seghatchian J, Bode AP.  Microvesicles in Blood Components: Laboratory and Clinical Aspects.  Clin Appl Thrombosis/Hemostasis.  1997;3:86-95.

  Fig 1:  Microvesicles in Blood Components 

4. Read MS, Bode AP.  Platelet Storage: Efforts to Extend the Shelf-Life of Platelet Concentrates.  Molecular Medicine Today.  1995:1:322-328.

   Fig 2:  Liquid to Lyophilized Plt Concentrate

 

   Fig 3:  Facets of Storage Lesion

5. Bode AP. Preclinical Testing of Lyophilized Platelets as a Product of Transfusion Medicine.  Transfusion Science.  1996;16:183-185.