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Faculty
Rank
Assistant Professor
Education
Shanghai Medical University,
M.D. (1982)
University of Southern California, Ph. D. (1996)
Internship
Shanghai Zhongshan Hospital,
China
Residency
Indiana University, Anatomic
and Clinical Pathology
Fellowship
Indiana University, Surgical
Pathology Fellowship
Duke University,
Cytopathology Fellowship
Boards
American Board of Pathology,
Anatomic Pathology
American Board of Pathology,
Clinical Pathology
American Board of Pathology,
Cytopathology
Clinical
Interests
Surgical pathology,
cytopathology
Research
Interests
Prostate cancer.
Nuclear receptor
coactivators and their biological roles in the
pathogenesis of hormone-dependent tumors.
Selected
Publications
Wang T,
Chen YH, Hong H, Zeng Y, Zhang J, Lu JP,
Jeansonne B and Lu Q: Increased nucleotide polymorphic
changes in the 5'-untranslated region of d-catenin
(CTNND2) gene in prostate cancer. Oncogen
28(4):555-64, 2009.
Hong
H,
Kao C, Jeng MH, Eble JN, Koch MO, Gardner TA, Zhang S,
Li L, Pan CX, Hu Z, MacLennan GT, Cheng L: Aberrant
Expression of CARM1, a transcriptional coactivator of
androgen receptor, in the development of prostate
carcinoma and androgen-independent status. Cancer
101(1):83-89, 2004.
Hong
H,
Koch MO, Foster RS, Bihrle R, Gardner TA, Fyffe J,
Ulbright TM, Eble JN, Cheng L: Anatomic distribution of
periprostatic adipose tissue. Cancer 97(7):1639-43,
2003.
Yang L,
Guerrero J, Hong H, DeFranco DB, Stallcup MR.:
Interaction of the tau2 transcriptional activation
domain of glucocorticoid receptor with a novel steroid
receptor coactivator, Hic-5, which localizes to both
focal adhesions and the nuclear matrix. Mol Biol Cell.
11(6):2007-18, 2000.
Xie W,
Hong H, Yang NN, Lin RJ, Simon CM, Stallcup MR,
Evans RM.: Constitutive activation of transcription and
binding of coactivator by estrogen-related receptors 1
and 2. Mol Endocrinol. 13(12):2151-62, 1999.
Ma H,
Hong H, Huang SM, Irvine RA, Webb P, Kushner PJ,
Coetzee GA, Stallcup MR.: Multiple signal input and
output domains of the 160-kilodalton nuclear receptor
coactivator proteins. Mol Cell Biol. 19(9):6164-73,
1999.
Hong
H,
Yang L, Stallcup MR: Hormone-independent
transcriptional activation and coactivator binding by
novel orphan nuclear receptor ERR3. J Biol Chem.
274(32):22618-26, 1999.
Chen D,
Ma H, Hong H, Koh SS, Huang SM, Schurter BT,
Aswad DW, Stallcup MR.: Regulation of transcription by
a protein methyltransferase. Science. 284(5423):2174-7,
1999.
Hong
H,
Darimont BD, Ma H, Yang L, Yamamoto KR, Stallcup MR.:
An additional region of coactivator GRIP1 required for
interaction with the hormone-binding domains of a subset
of nuclear receptors. J Biol Chem. 274(6):3496-502,
1999.
Ding XF,
Anderson CM, Ma H, Hong H, Uht RM, Kushner PJ,
Stallcup MR.: Nuclear receptor-binding sites of
coactivators glucocorticoid receptor interacting protein
1 (GRIP1) and steroid receptor coactivator 1 (SRC-1):
multiple motifs with different binding specificities.
Mol Endocrinol. 12(2):302-13, 1998.
Milhon
J, Lee S, Kohli K, Chen D, Hong H, Stallcup MR.:
Identification of amino acids in the tau 2-region of the
mouse glucocorticoid receptor that contribute to hormone
binding and transcriptional activation. Mol Endocrinol.
11(12):1795-805, 1997.
Welch
CL, Xia YR, Hong H, Stallcup MR, Lusis AJ.:
Localization of the mouse glucocorticoid
receptor-interacting protein 1 gene (Grip1) to proximal
chromosome 1 by linkage analysis. Mamm Genome.
8(8):620-1, 1997.
Hong
H,
Kohli K, Garabedian MJ, Stallcup MR.: GRIP1, a
transcriptional coactivator for the AF-2 transactivation
domain of steroid, thyroid, retinoid, and vitamin D
receptors. Mol Cell Biol. 17(5):2735-44, 1997.
Walfish
PG, Yoganathan T, Yang YF, Hong H, Butt TR,
Stallcup MR.: Yeast hormone response element assays
detect and characterize GRIP1 coactivator-dependent
activation of transcription by thyroid and retinoid
nuclear receptors. Proc Natl Acad Sci U S A.
94(8):3697-702, 1997.
Hong
H,
Kohli K, Trivedi A, Johnson DL, Stallcup MR.: GRIP1, a
novel mouse protein that serves as a transcriptional
coactivator in yeast for the hormone binding domains of
steroid receptors. Proc Natl Acad Sci U S A.
93(10):4948-52, 1996.
Selected
Abstract
Hong H
and Dobbs L: An unusual case of extrahepatic bile duct
adenoma with a neuroendocrine component. Southern
Medical Association Annual Scientific Assembly.
Nashville, TN, 2008.
Wang T,
Kim K, Chen YH, Hong H, and Lu Q: Transcriptional
regulation of δ-catenin/NPRAP/neurojungin (CTNND2) gene
expression in human prostate cancer. The American
Society for Cell Biology 47th Annual Meeting.
Washington, DC, 2007.
Hong
H,
Rugnath D, Hewan-Lowe K, Strausbauch P and MacDonald KG:
Ectopic liver attached to the gallbladder: light
microscopy and ultrastructural features. Southern
Medical Association Annual Scientific Assembly. New
Orleans, LA, 2007.
Hong
H,
Finley J, and Thomas S: Unusual reticulin staining
pattern in a case of well-differentiated hepatocellular
carcinoma. Southern Medical Association Annual
Scientific Assembly. New Orleans, LA, 2007.
Finley J
and Hong H: Fine needle aspiration cytology of
pancreatic rhabdoid tumor: report of two cases.
Southern Medical Association Annual Scientific
Assembly. New Orleans, LA, 2007.
Wang T,
Chen YH, Jeansonne B, Hong H, Zeng Y, Kim K,
Bareiss S, and Lu Q: Analyses of δ-catenin gene
overexpression in human prostate cancer. AACR Annual
Meeting, Los Angeles, CA, 2007.
Hong
H,
Kao C, Jeng M, Eble JN, Koch MO, Gardner TA, Zhang S, Li
L, Hu Z, MacLennan GT, Cheng L: Overexpression of CARM1,
a Transcriptional Coactivator of Androgen Receptor, in
Prostatic Adenocarcinoma and Its Precursors. Annual
Meeting of United States and Canadian Academy of
Pathology, Vancouver, Canada, 2004.
Hong
H,
Koch MO, Ulbright TM, Eble JN, and Cheng L: A
Quantitative Analysis of Periprostatic Adipose Tissue: A
Dilemma for the Staging of Prostate Cancer. Annual
Meeting of United States and Canadian Academy of
Pathology, Chicago 2002.
Chen DG,
Hong H, Huang SM, Subramanian S, and Stallcup MR:
A novel mouse protein that specifically interacts with
the C-terminal activation domain of GRIP1. Keystone
Symposium on Nuclear Receptors, Lake Tahoe, California,
1998.
Hong
H,
Yang L and Stallcup MR: A Newly Identified Region in
GRIP1 Is Important for the Interaction with
Glucocorticoid Receptor. Keystone Symposium on Nuclear
Receptors, Lake Tahoe, California, 1998.
Hong
H,
Kohli K, and Stallcup MR: Mouse GRIP1 functions as a
transcription co-activator for steroid receptors in
yeast by interaction with the AF-2, but not the AF-1
domain. FASEB Summer Research Conference
"Transcriptional Regulation", Snowmass Village,
Colorado, August, 1996.
Hong
H,
Kohli K, Trivedi A, Johnson DL, and Stallcup MR: GRIP1,
a novel mouse protein that serves as a transcriptional
co-activator in yeast for the hormone binding domains of
steroid receptors. American Association for Cancer
Research Special conference "The Molecular Basis of Gene
Transcription", San Diego, California, 1995.
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